Jul 14 – 19, 2024
Georgia State University College of Law
America/New_York timezone
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Residential segregation of Latinx residents in California is associated with worse brain health measured via brain imaging

Jul 16, 2024, 11:00 AM
20m
Knowles Conference Center/Second Level-246 - Room 246 (Georgia State University College of Law)

Knowles Conference Center/Second Level-246 - Room 246

Georgia State University College of Law

50
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Paper Structural Determinants of Health Paper Presentations

Speaker

Lilah Besser (University of Miami)

Description

Residential segregation in the US has been associated with worse cognitive functioning in Black older adults, but the impact of segregation on Latinx individuals is less clear from published studies. We investigated whether Latinx individuals living in more segregated Latinx neighborhoods had worse brain health measured via magnetic resonance imaging (MRI). We analyzed data on 202 non-Hispanic White and Latinx older adults with normal cognition or mild cognitive impairment living in California and participating in research at the University of California Davis Alzheimer’s Disease Research Center. MRI outcomes included hippocampal volume, which when reduced is a risk factor for Alzheimer’s disease (AD), and white matter hyperintensity (WMH) volume, which when increased indicates white matter damage that increases risk for dementia including AD and cerebrovascular disease (e.g., stroke). Latinx segregation was defined using the Getis-Ord (Gi*) statistic, which compares the proportion of Latinx residents in the participant’s neighborhood (US Census tract) to the surrounding neighborhoods and greater study region (higher scores: greater clustering/segregation). Multivariable linear regression analyses examined associations between Latinx segregation and the MRI outcomes. Living in neighborhoods with greater Latinx segregation was associated with greater WMH volume among the Latinx but not White participants. No association was found between segregation and hippocampal volume for either race/ethnicity. Our findings suggest worse brain health among Latinx individuals living in more segregated neighborhoods. Future studies need to replicate these findings and elucidate potential causal mechanisms (e.g., Latinx segregated neighborhoods may have fewer recreational, greenspace, and physical activity resources to promote healthy lifestyles).

Primary author

Lilah Besser (University of Miami)

Co-authors

Dr Charles DeCarli (University of California Davis) Dr Diana Mitsova (Florida Atlantic University) Dr Oanh Meyer (University of California Davis) Dr Pauline Maillard (University of California Davis) Dr Sarah Forrester (University of Massachusetts)

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